Cisdiamminedichloroplatinum

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WebApr 19, 2024 · A platinum-based chemotherapeutic agent, Cisplatin (CDDP), has been widely used to treat many human cancer including cervical cancer, metastatic cancers and most of other solid tumors [1]. The cisplatin anticancer efficacy is owing to its interaction with chromosomal DNA. WebThree Co(III) complexes of a designed ligand PMAH that mimics the metal-binding domain of the antitumor antibiotic bleomycin (BLM) have been isolated and structurally characterized. The coordination

Characterization of a cis-Diamminedichloroplatinum(II)-resistant …

WebCis-diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations T. W. Jones, S. Chopra, J. S. Kaufman, W. … WebDec 3, 1979 · [Cis-diamminedichloroplatinum(II). A new antineoplastic agent derived from the group of heavy metal complexes (author's transl)] Platinum coordination complexes represent a new class of antineoplastic agents among which only cis-diamminedichloroplatinum(II) (cis-DDP) has undergone extensive clinical trials. flying eagle f5s eclipse skates

Enhanced therapeutic effect of cis-diamminedichloroplatinum (II ...

WebWe demonstrated previously that the effect of cis-diamminedichloroplatinum(II) (cisplatin) against pancreatic cancer was substantially enhanced by the addition to the … WebSpectrum of cis-diamminedichloroplatinum (II)-induced mutations in a shuttle vector propagated in human cells Spectrum of cis-diamminedichloroplatinum (II)-induced mutations in a shuttle vector propagated in human cells Authors G J Bubley 1 , B P Ashburner , B A Teicher Affiliation WebJun 1, 1975 · Summary. The effects of cis -diamminedichloroplatinum (NSC 119875) on murine and human hemopoietic precursor cells were studied in culture. When murine … flying eagle coin shop

cis-Diamminedichloroplatinum in the treatment of advanced …

Cis-diamminedichloroplatinum definition of Cis ...

WebCisplatin (cis-Diamminedichloroplatinum) is a organometallic compound and one of several platinum-based antineoplastic agents used in certain types of chemotherapy for the treatment of cancer. These compounds, … WebApr 20, 2016 · miR-3188 suppresses cell growth and 5-FU chemoresistance. To identify the role of miR-3188 in NPC development, we first examined its expression levels in normal epithelium (NP) and NPC cell lines. miR-3188 expression was elevated in NP69 and SXSW-1489 cells but weakly expressed in NPC cells (Fig. 1a).To further explore its biological … flying eagle furniture outletWebA total of 26 patients with biopsy proved epidermoid carcinoma of the penis (Jackson stage III or IV) with measurable disease, no prior chemotherapy and adequate renal function received 50 mg. per M.2 cis-diamminedichloroplatinum intravenously on days 1 … flying eagle fbs

"WebJun 1, 1973 · cis -Diamminedichloroplatinum (II) is the first of a group of platinum coordination complexes with antineoplastic activity to be studied in humans. This Phase I investigation characterizes the toxicity and pharmacological disposition of … " - Cisdiamminedichloroplatinum

Cisdiamminedichloroplatinum

WebCis-diamminedichloroplatinum (II) (DDP) leads the series of platinum coordination complexes, a new class of cytotoxic agents. The antitumor and toxic effects of this drug …

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Weba platinum coordination compound whose main mode of action resembles that of alkylating agents with production of cross links between the two strands of DNA in the double helix … WebAbstract. Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis-diamminedichloroplatinum, vinblastine, and bleomycin. …

WebMay 15, 2015 · The interest in gold(III) as anticancer agent is a result of the current significance of the anticancer cisplatin, cis-diamminedichloroplatinum(II), [PtCl 2 (NH 3) 2] . Although cisplatin has been used for a long time for the treatment of different types of cancer there are several limitations and drawbacks. Gold(III) compounds provided ... Webcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells Pharmacol Ther. 1984;25(3):297-326.doi: 10.1016/0163 …

Webcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells Pharmacol Ther. 1984;25(3):297-326.doi: 10.1016/0163-7258(84)90003-2. Author E B Douple PMID: 6542679 DOI: 10.1016/0163-7258(84)90003-2 No abstract available Publication types Webcis-Diamminedichloroplatinum (II) induced distortion in a double-helical DNA fragment jeroen den hartog 1984, Journal of The American Chemical Society Download Free PDF Related Papers Journal of the … Mechanism of two-electron oxidation of deoxyguanosine 5'-monophosphate by a platinum (IV) complex 2004 • Amanda Hakemian Download Free …

WebA regression rate of 12% (4/33) among patients with advanced upper aerodigestive carcinomas who received an intravenous regimen of cis‐diamminedichloroplatinum, …

Webtrans-Platinum(II) diamminedichloride Cl2H6N2Pt+2 CID 441203 - structure, chemical names, physical and chemical properties, classification, patents, literature ... green lights matthew mcconWebJul 4, 1995 · The combination of cis-diamminedichloroplatinum(II) (CDDP) and 7-ethyl-10-[4-(I -piperidino)-I -piperidino]carbonyloxycamptothecin (CPT-I I), a topoisomerase-l inhibitor, has been shown to be synergistic in vitro and clinically active against several human cancers refractory to chemotherapy. To elucidate the mechanism of the … greenlights matthew mcconaughey audioWebAbstract Cis-diamminedichloroplatinum (DDP) was used as the initial treatment in a pilot study of 17 patients with biopsy-proven transitional cell carcinoma of the bladder. No … greenlights matthew mcWebCisplatin (cis-diamminedichloroplatinum II) Cisplatin (cis-diamminedichloroplatinum II) Cisplatin (cis-diamminedichloroplatinum II) Cancer Treat Rev. 1979 Mar;6(1):17-39. doi: … green lights lyrics nfWebNov 1, 1983 · cis -Platinum, bleomycin, 5-fluorouracil, and cyclophosphamide were administered to rodent and canine models of osmotic blood-brain barrier modification to evaluate the relationship between tissue drug concentration in brain and the physiological and neuropathological effects of the drug. greenlights matthewWeb目的应用免疫组化方法观察豚鼠内耳S-100蛋白的表达。方法选用健康,Preyer’s反射正常豚鼠8只,4%多聚甲醛活体灌注后耳蜗冰冻切片,采取SP免疫组化方法进行S-100蛋白染色。结果耳蜗Corti’s器内外毛细胞,Deiter及Hensen细胞呈阳性表达,基底膜下细胞未着色,螺旋缘齿间细胞,螺旋神经节细胞间纤维,螺旋韧带及 ... green lights kyd the bandWeb1-β-D-Arabinofuranosylcytosine (ara-C) and hydroxyurea (HU) were investigated as possible inhibitors for the repair of cis-diamminedichloroplatinum(II) (DDP)-induced DNA damage. HU and ara-C were chosen for their known ability to … greenlights matthew mcconaughey