Cub domain-containing protein
WebCUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. It has also been designated as CD318 (cluster of differentiation 318) and … WebCUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. CDCP1 has also been designated as CD318 (cluster of differentiation …
Cub domain-containing protein
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WebOct 1, 2024 · CUB domain-containing protein 1 (CDCP1) is a transmembrane glycoprotein that contains three extracellular CUB domains and regulates anchorage … WebFeb 15, 2024 · CUB domain containing protein 1 (CDCP1), also known as Trask, gp140, SIMA135, and CD318, is a type I single-pass membrane protein that is highly overexpressed in a variety of solid tumors (12 – 14).
WebDec 13, 2024 · Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ... XM_047418383.1 → XP_047274339.1 signal peptide, CUB and EGF-like domain-containing protein 3 isoform X4. XM_047418382.1 → XP_047274338.1 signal peptide, CUB and EGF-like domain … WebJun 14, 2010 · CUB domain–containing protein 1 (CDCP1) is a membrane protein that is highly expressed in several solid cancers. We reported previously that CDCP1 regulates …
WebJul 10, 2012 · The deduced 993-amino acid protein has an N-terminal signal sequence, followed by 9 putative calcium-binding EGF-like repeats, a spacer region, and a C-terminal CUB domain. The spacer region contains 5 potential N-glycosylation sites. SCUBE3 was predicted to be secreted as a mature 971-amino acid protein with a calculated molecular … WebJul 15, 2024 · This study advances CUB domain-containing protein 1 (CDCP1) as a novel target for metastatic castration-resistant prostate cancer, in both adenocarcinoma and neuroendocrine subtypes. Combined with low expression in normal human tissues, these data provide a compelling scientific rationale for translating CDCP1-directed RLT into the …
WebMar 23, 2024 · The structure of CUB domains consists of a beta-sandwich with a jelly-roll fold. Almost all CUB domains contain four conserved cysteines that probably form two …
WebOct 1, 2024 · CUB domain-containing protein 1 (CDCP1) is one of the few transmembrane glycoprotein that contains three extracellular CUB domains and … ip location pullerWebOct 3, 2024 · Abstract. Rationale: An antibody-drug conjugate (ADC) is a targeted therapy consisting of a cytotoxic payload that is linked to an antibody which targets a protein … ip location redditWebOct 2, 2024 · Comment: annotation includes both PSPI/PSPII interaction residues highlighted. Download Cn3D for Viewing 3D Structure Scroll to Sequence Alignment … ip location locateWebDec 31, 2012 · Cub domain containing protein 1 (CDCP1) is strongly expressed in tumors derived from lung, colon, ovary, or kidney. It is a membrane protein that is phosphorylated and then bound by Src family … oral-b pro 600 floss actionWebFeb 15, 2024 · Here, we demonstrate that Abs that selectively recognize a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) could enable more effective … ip location queryWebSummary. This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. ip location headerWebDec 31, 2012 · Cub domain containing protein 1 (CDCP1) is strongly expressed in tumors derived from lung, colon, ovary, or kidney. It is a membrane protein that is phosphorylated and then bound by Src family kinases. Although expression and phosphorylation of CDCP1 have been investigated in many tumor cell lines, the CDCP1 features responsible for … ip location my