Web1 day ago · Mitochondrial oxidative phosphorylation (OXPHOS) provides the majority of ATP used to support placental energy demands, accounting up to 40% of the total oxygen (O 2) consumption by the gravid uterus in humans and ovine pregnancies [1]. ... fusion/fission dynamics, mitophagy, OXPHOS, antioxidant enzyme expression, and ROS production … WebAug 27, 2024 · Effector T cells have more punctate mitochondria as indicated by increased mitochondrial fission, which lead to lower OXPHOS and higher aerobic glycolytic rate . Moreover, mitochondrial fragmentation also promotes ROS production, which is required for acquisition of effector functions in activated T cells ( 37 ).
Frontiers Pivotal Role of Mitochondria in Macrophage Response …
WebApr 10, 2024 · Natural IL-17-producing γδ T cells (γδT17 cells) are unconventional innate-like T cells that undergo functional programming in the fetal thymus. However, the intrinsic metabolic mechanisms of γδT17 cell development remain undefined. Here, we demonstrate that mTORC2, not mTORC1, selectively controls the functional fate commitment of … WebApr 7, 2024 · Doxorubicin (DOX) has been recognized as one of the most effective chemotherapies and extensively used in the clinical settings of human cancer. However, DOX-mediated cardiotoxicity is known to compromise the clinical effectiveness of chemotherapy, resulting in cardiomyopathy and heart failure. Recently, accumulation of … budget inn downtown mobile al
Bioenergetic roles of mitochondrial fusion - ScienceDirect
WebJul 15, 2024 · Mitochondrial fission is necessary for both pluripotential and metabolic reprogramming , in which a metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis has been found to be beneficial for stem cells, including CSCs, for self-renew and maintenance of stem cell states . WebMar 18, 2024 · A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are unclear. Here we show that the M2 isoform of pyruvate kinase (PKM2), … WebOur data suggest that, by altering cristae morphology, fusion in T M cells configures electron transport chain (ETC) complex associations favoring oxidative phosphorylation (OXPHOS) and FAO, while fission in T E cells leads to cristae expansion, reducing ETC efficiency and promoting aerobic glycolysis. Thus, mitochondrial remodeling is a ... criedlich